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Reactive extraction of enantiomers of 1,2-amino alcohols via stereoselective thermodynamic and kinetic processes.

Tang L, Choi S, Nandhakumar R, Park H, Chung H, Chin J, Kim KM

Division of Nano Sciences, Ewha Womans University, Seoul 120-750, South Korea.

(R)-amino alcohol with an enantiomeric excess of >95% was resolved by reactive extraction processes from 2 equiv of racemic alcohol using a chiral receptor 2 as an enantioselective extractant. One resolution cycle is composed of three extractions: a stereoselective reversible imine formation, a stereoselective irreversible imine hydrolysis, and the recovery of 2 and enantiomeric amino alcohols.

Published 28 July 2008 in J Org Chem, 73(15): 5996-9.
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