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Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data.

Delgado R, Félix V, Lima LM, Price DW

Instituto de Tecnologia Química e Biológica, UNL, Apartado 127, 2781-901, Oeiras, Portugal. delgado@itqb.unl.pt

A series of the most common chelators used in magnetic resonance imaging (MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X-ray structures and theoretical studies.

Published 26 June 2007 in Dalton Trans.
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